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科学研究 > 科研方向

科学研究

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科学研究

张学记

职位：教授


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简介

人员

主要研究方向

1.MicroRNA生物分析：
设计多种高效特异的核酸识别探针，将纳米技术引入到microRNA生物传感中探针固定，信号转导及信号放大各个环节，构建集细胞转染、示踪及胞内microRNA检测的纳米多功能载体，创新检测原理及信号放大策略，从胞外、细胞到活体不同层次，从单一到多元microRNA、前体（pre-microRNA）到成熟microRNA不同维度，发展了一系列高效的microRNA标志物分子检测新方法。

 

2.纳米诊疗：
可控合成具有独特光学、磁学性能的纳米材料发展有效的表面修饰及细胞膜包裹技术，赋予纳米材料良好的生物相容性、靶向性、长的循环时间及有效体内清除能力，构建具有荧光成像、光声成像（PAI）、磁成像（MRI）及CT多模式成像及光热（PTT）、光动力（PDT）与超声动力（SDT）等功能纳米探针，实现肿瘤精准成像检测与治疗。

 

3.电化学与电化学生物传感器：
设计和调控电催化剂与反应分子的相互作用，开发性能优良的电催化剂。以微纳电极为载体，制备一体化传感涂层，调控特异性识别元件与电极之间的信号转换，实现对目标分析物的定量检测。

 

4.智能可穿戴传感器:
研发导电纤维，将生物传感器技术与导电纤维技术进行交叉融合，结合5G通信、人工智能和大数据等与生物传感技术的融合发展趋势，围绕柔性电子和植入式材料与器件、多维度感知和人-机-自然交互等关键方向，围绕智能可穿戴主题，开展智能可穿戴材料、可穿戴检测技术、柔性智能可穿戴设备及智能服装的研发和产业化，为带动智能可穿戴行业的快速发展提供理论与技术支撑。

 

5.智能微纳米马达:
人工微纳米马达是效仿自然界中的生物分子马达制备而成的微纳尺度动力装置，具有稳定性高、制备简单、可批量生产等优点，在生物医学领域有广阔的应用前景。本方向将发展磁能、电能、声能、光能及热能等多种控制微纳米马达运动的方式. 结合对微纳米马达的功能化修饰，实现微纳米马达运动的方向和速度的精确控制以及核酸、蛋白质、细胞以及细菌等的装载、运输、释放和检测等精准操作。

 

6.基于超小纳米发光材料的生物传感、成像、控释体系:
致力于超小发光纳米材料以及发光纳米生物传感器的研究，将纳米簇的刻蚀化学延伸到聚集诱导发光（AIE）效应领域的研究，开创了“由上到下”制备AIE型金(I)配合物的新方法。同时开展刺激-响应性微凝胶的应用，通过将微凝胶中装入不同的功能纳米材料，有机地结合微凝胶本身的刺激-响应性质，实现该材料的多种新应用，包括光热治疗、有机物降解以及分析传感等。

 

7.功能手性无机纳米材料的合成及其在生物医用、不对称催化中的应用:
手性材料能够表现出特殊的光、电、磁等性质，近年来已被大量应用于信息加密、不对称催化、光电催化、生物传感、生物治疗、手性光电器件、偏振控制显示等领域，获得了不同学科领域的广泛关注。我们将致力于从原子水平上揭示手性无机功能材料的手性起源，实现可控构筑功能手性纳米材料，并进一步研究其相关性能及构效关系。应用方面主要集中在探索手性无机纳米材料在生物医用领域中的应用如手性蛋白/手性分子识别、生物传感、手性药物拆分，及不对称催化的研究。

 

主要成果

1. Songsong Tang,# Fangyu Zhang,# Hua Gong,# Fanan Wei, Jia Zhuang, Emil Karshalev, Berta Esteban-Fernández de Ávila, Chuying Huang, Zhidong Zhou, Zhengxing Li, Lu Yin, Haifeng Dong, Ronnie H. Fang, Xueji Zhang,* Liangfang Zhang,* Joseph Wang.* Enzyme-powered Janus platelet cell robots for active and targeted drug delivery. Science Robotics 2020, 5, eaba6137.
2. Conghui Liu, Yu Cao, Yaru Cheng, Dongdong Wang, Tailin Xu, Lei Su, Xueji Zhang,* Haifeng Dong.* An open source and reduce expenditure ROS generation strategy for chemodynamic/ photodynamic synergistic therapy. Nature Communications 2020, 11, 1735
3. Shah Zada,# Wenhao Dai,# Zhang Kai, Huiting Lu, Xiangdan Meng, Yiyi Zhang, Yaru Cheng, Fang Yan, Pengcheng Fu, Xueji Zhang,* Haifeng Dong.* Algae extraction controllable delamination of vanadium carbide nanosheets with enhanced near-infrared photothermal performance. Angewandte Chemie International Edition 2020, 59, 6601-6606
4. Yanming Zhao,# Wenhao Dai,# Yunlei Peng, Zheng Niu, Qi Sun, Chuan Shan, Hui Yang, Gaurav Verma, Lukasz Wojtas, Daqiang Yuan, Zhenjie Zhang,* Haifeng Dong,* Xueji Zhang,* Bao Zhang,* Yaqing Feng, Shengqian Ma.* A corrole-based covalent organic framework featuring desymmetrized topology. Angewandte Chemie International Edition 2020, 59, 4354 -4359
5. Yongchao Song, Tailin Xu,* Xin Song, Xueji Zhang.* Integrated microdroplets array for intelligent electrochemical fabrication. Advanced Functional Materials 2020, 30, 1910329
6. Yiyi Zhang, Yaru Cheng, Fan Yang, Zhipeng Yuan, Wei Wei, Huiting Lu,* Haifeng Dong,* Xueji Zhang. Near-infrared triggered Ti3C2/g-C3N4 heterostructure for mitochondria-targeting multimode photodynamic therapy combined photothermal therapy. Nano Today 2020, 34, 100919
7. Xili Hu, Mingwei Tian,* Tailin Xu,* Xuantong Sun, Bing Sun, Chengcheng Sun, Xuqing Liu, Xueji Zhang,* Lijun Qu.* Multiscale disordered porous fibers for self-sensing and self-cooling integrated smart sportswear. ACS Nano 2020, 14, 559-567
8. Kai Zhang, Xiangdan Meng, Zhou Yang,* Haifeng Dong,* Xueji Zhang. Enhanced cancer therapy by hypoxia-responsive copper metal-organic frameworks nanosystem. Biomaterials 2020 258, 120278
9. Fengqiang Sun, Mingwei Tian,* Xuantong Sun, Tailin Xu,* Xuqing Liu, Shifeng Zhu, Xueji Zhang,* Lijun Qu.* Stretchable conductive fibers of ultrahigh tensile strain and stable conductance enabled by a worm-shaped graphene microlayer. Nano Letters 2019, 19, 6592-6599
10. Tailin Xu, Li-Ping Xu,* Xueji Zhang,* Shutao Wang.* Bioinspired superwettable micropatterns for biosensing. Chemical Society Reviews 2019, 48, 3153-3165
11. Kai Zhang, Xiangdan Meng, Zhou Yang, Yu Cao, Yaru Cheng, Dongdong Wang, Huiting Lu, Zhuojie Shi, Haifeng Dong,* Xueji Zhang. Cancer cell membrane camouflaged nanoprobe for catalytic ratiometric photoacoustic imaging of microRNA in living mice. Advanced Materials 2019, 31, e1807888.
12. Yansheng Li, Yanli Ma, Xiangyu Jiao, Tingyu Li, Zhehao Lv, Chaoyong James Yang,* Xueji Zhang,* Yongqiang Wen.* Control of capillary behavior through target-responsive hydrogel permeability alteration for sensitive visual quantitative detection. Nature Communications 2019, 10, 1036.
13. Yaru Cheng, Fan Yang, Kai Zhang, Yiyi Zhang, Yu Cao, Conghui Liu, Huiting Lu, Haifeng Dong,* and Xueji Zhang. Non-fenton-type hydroxyl radical generation and photothermal effect by mitochondria-targeted WSSe/MnO2 nanocomposite loaded with isoniazid for synergistic anticancer treatment. Advanced Functional Materials 2019, 29, 1903850
14. Conghui Liu, Dongdong Wang, Shuyuan Zhang, Yaru Cheng, Fan Yang, Yi Xing, Tailin Xu, Haifeng Dong,* Xueji Zhang.* Biodegradable biomimic copper/manganese silicate nanospheres for chemodynamic/photodynamic synergistic therapy with simultaneous glutathione depletion and hypoxia relief. ACS Nano 2019, 13, 4267-4277.
15. Yu Cao, Tingting Wu, Kai Zhang, Xiangdan Meng, Wenhao Dai, Dongdong Wang, Haifeng Dong,* Xueji Zhang.* Engineered exosome-mediated near-infrared-ii region V2C quantum dot delivery for nucleus-target low-temperature photothermal therapy. ACS Nano 2019, 13, 1499-1510.

16. Yaru Cheng, Fan Yang, Guolei Xiang, Kai Zhang, Yu Cao, Dongdong Wang, Haifeng Dong,* Xueji Zhang.* Ultrathin tellurium oxide/ammonium tungsten bronze nanoribbon for multimodality imaging and second near-infrared region photothermal therapy. Nano letters 2019, 19, 1179-1189
17. Kai Zhang, Zhaofeng Yu, Xiangdan Meng, Weidong Zhao, Zhuojie Shi, Zhou Yang,* Haifeng Dong,* Xueji Zhang. A bacteriochlorin-based metal-organic framework nanosheet superoxide radical generator for photoacoustic imaging-guided highly efficient photodynamic therapy. Advanced Science 2019, 6, 1900530
18. Kai Zhang, Xiangdan Meng, Yu Cao, Zhou Yang,* Haifeng Dong,* Yuedong Zhang, Huiting Lu, Zhuojie Shi, Xueji Zhang, Metal-organic framework nanoshuttle for synergistic photodynamic and low-temperature photothermal therapy. Advanced Functional Materials 2018, 28, 1804634
19. Dongdong Wang, Haifeng Dong,* Meng Li, Yu Cao, Fan Yang, Kai Zhang, Wenhao Dai, Changtao Wang, Xueji Zhang.* Erythrocyte-cancer hybrid membrane camouflaged hollow copper sulfide nanoparticles for prolonged circulation life and homotypic-targeting photothermal/chemotherapy of melanoma. ACS Nano 2018, 12, 5241-5252.
20. Yu Cao, Shuzhou Li, Chao Chen, Dongdong Wang, Tingting Wu, Haifeng Dong,* Xueji Zhang.* Rattle-type Au@Cu2-xS hollow mesoporous nanocrystals with enhanced photothermal efficiency for intracellular oncogenic microRNA detection and chemo-photothermal therapy. Biomaterials 2018, 158, 23-33.
21. Kai Zhang, Yuedong Zhang, Xiangdan Meng, Huiting Lu, Huan Chang, Haifeng Dong,* Xueji Zhang.* Light-triggered theranostic liposomes for tumor diagnosis and combined photodynamic and hypoxia-activated prodrug therapy. Biomaterials 2018, 185, 301-309.
22. Tailin Xu, Wanxin Shi, Jinrong Huang, Yongchao Song, Feilong Zhang, Li-Ping Xu,* Xueji Zhang,* Shutao Wang.* Superwettable microchips as a platform toward microgravity biosensing. ACS Nano 2017, 11, 621-626.
23. Tailin Xu, Wei Gao, Li‐Ping Xu,* Xueji Zhang,* Shutao Wang.* Fuel-free synthetic micro-/nanomachines. Advanced Materials 2017, 29, 1603250.
24. Fei Wu,# Lei Su,# Ping Yu, Lanqun Mao.* Role of organic solvents in immobilizing Laccase on single-walled carbon nanotubes for improved current response in direct bioelectroanalysis. Journal of the American Chemical Society 2017, 139, 1565-1574.
25. Xiangdan Meng, Zhiqiang Liu, Yu Cao, Wenhao Dai, Kai Zhang, Haifeng Dong,* Xiaoyan Feng,* Xueji Zhang.* Fabricating aptamer-conjugated pegylated-MoS2/Cu1.8S theranostic nanoplatform for multiplexed imaging diagnosis and chemo-photothermal therapy of cancer. Advanced Functional Materials 2017, 27, 1605592.
26. Huayan Yang,# Juanzhu Yan,# Yu Wang, Guocheng Deng, Haifeng Su, Xiaojing Zhao, Chaofa Xu, Boon K. Teo,* and Nanfeng Zheng.* From racemic metal nanoparticles to optically pure enantiomers in one pot. Journal of the American Chemical Society 2017, 139, 16113-16116
27. Huayan Yang, Juanzhu Yan, Yu Wang, Haifeng Su, Lars Gell, Xiaojing Zhao, Chaofa Xu, Boon K. Teo,* Hannu Hakkinen,* Nanfeng Zheng.* Embryonic growth of face-center-cubic silver nanoclusters shaped in nearly perfect half-cubes and cubes. Journal of the American Chemical Society 2017, 139, 31-34.
28. Huayan Yang, Yu Wang, Xi Chen, Xiaojing Zhao, Lin Gu, Huaqi Huang, Juanzhu Yan, Chaofa Xu, Gang Li, Junchao Wu, Alison J. Edwards,* Birger Dittrich, Zichao Tang, Dongdong Wang, Lauri Lehtovaara, Hannu Ha¨kkinen,* Nanfeng Zheng.* Plasmonic Twinned Silver Nanoparticles with Molecular Precision. Nature Commununications 2016, 7, 12809.
29. Xinchang Wang,* Yu Wang,* Huayan Yang, Hongxun Fang, Ruixue Chen, Yibin Sun, Nanfeng Zheng, Kai Tan, Xin Lu, Zhongqun Tian, Xiaoyu Cao. Assembled Molecular Face-rotating Polyhedra to Transfer Chirality from Two to Three Dimensions. Nature Communications 2016, 7, 12469.
30. Yang, Huayan, Yu Wang, Huaqi Huang, Lars Gell, Lauri Lehtovaara, Sami Malola, Hannu Hakkinen, and Nanfeng Zheng. All-Thiol-Stabilized Ag44 and Au12Ag32 Nanoparticles with Single-Crystal Structures. Nature Commun. 2013, 4, 2422.