教育经历 

·1988-1992年，加拿大多伦多大学，工程科学系，获学士（荣誉）学位 
·1992-1994年，加拿大多伦多大学，物理系，获硕士学位，Prof. R Marjoribanks 
·1994-2000年，加拿大多伦多大学，医学生物物理系，获博士学位,Prof. P Burns 

 主要工作经历 

·2001-2003年,荷兰鹿特丹大学,研究科学家 
·2001-2003年,瑞士Bracco研究中心,项目科学家（兼职） 
·2003-2010年,飞利浦研究院（北美）,资深科学家 
·2010年-至今，深圳大学，医学院生物医学工程系，教授、教学研究室副主任 

 荣誉和奖励 

·最佳会议海报，美国心脏学会， 2008 
·杰出团队奖（新创造奖），飞利浦北美研究中心， 2007 
·杰出团队奖（超声基因转染），飞利浦北美研究中心， 2006 
·特邀论文－第4届国际超声造影成像大会， 2002 
·特邀论文－第6届欧洲超声造影成像大会， 2001 
·特邀论文－第5届欧洲超声造影成像大会， 2000 
·特邀论文－第135届美国声学学会年会， 1998 
·优秀论文奖－加拿大医学物理学年会， 1998 
·青年科学家奖－第3届欧洲超声造影成像大会，1998 

 国际专利（共19项，部分如下）
 
1. C T Chin, C S Hall, A L Klibanov; Device and method of tumor treatment using ultrasound cavitatio, (US 61/169355) 
2. C T Chin, C S Hall, K Tiemann, A Ghanem; Ultrasound enhanced stem cell delivery device and method, (US 61/089642) 
3. C T Chin, C S Hall, D L M Savery, S Sokka; Microbubble Generating Technique For Phase Aberration Correction (US 2008/10208059 A1; WO2006095288 A1) 
4. M Averkiou, C T Chin, C S Hall, D L M Savery, S Sokka; Method and Apparatus for the Visualization of the Focus Generated Using Focused Ultrasound (US 2008/0208059 A1 

 科研成果 

 SCI 期刊论文： 

1. Yuanyuan Shen, Tianfu Wang, C T Chin, Xianfen Diao and Siping Chen, Study on Interaction Between Microbubble and Elastic Microvessel in Low Frequency Ultrasound Field Using Finite Element Method, Chinese Science Bulletin, （in review）. 

2. 邱晓晖，沈圆圆，钱建庭，刁现芬，汪天富，陈思平，刚性微管内微泡动力学行为的有限元数值分析，生物医学工程学杂志，2011年第5期。（non-SCI） 

3. A L Klibanov, T I Shevchenko, B I Raju, R Seip, C T Chin, Ultrasound-triggered release of materials entrapped in microbubble-liposome constructs: a tool for targeted drug delivery. J Controlled Release 2010; 148(1):13-17. 

4. M R Böhmer, C H T Chlon, B I Raju, C T Chin, T Shevchenko, A L Klibanov, Focused ultrasound and microbubbles for enhanced extravasation. J Controlled Release 2010; 148(1):18-24. 

5. R Seip, C T Chin, C Hall, B I Raju, A Ghanem, K Tiemann, Targeted Ultrasound Mediated Delivery of Nanoparticles: on the development of a new HIFU-based therapy and imaging device, IEEE Trans. Biomed. Eng.  2009; 57(1):61-70. 

6. A Ghanem, C Steingen, F Brenig, F Funcke, Z-Y Bai, C Hall, C T Chin, G Nickenig, W Bloch, K Tiemann, Focused ultrasound-induced stimulation of microbubbles augments site-targeted engraftment of mesenchymal stem cells after acute myocardial infarction, J. Mol. Cell. Card. 2009; 47:411-8. （被引用6次ISI） 

7. S M van der Meer, B Dollet, M M Voormolen, C T Chin, A Bouakaz, N de Jong, M Versluis, D Lohse, Microbubble spectroscopy of ultrasound contrast agents, J. Acoust. Soc. Am. 2007; 121:648-56（被引用39次ISI） 

8. N de Jong, M Emmer, C T Chin, A Bouakaz, F Mastik, D Lohse and M Versluis, “Compression-Only” Behavior of Phospholipid-Coated Contrast Bubbles, Ultrasound Med Biol. 2007; 33(4):653-656（被引用27次ISI） 

9. J M G Borsboom, C T Chin, A Bouakaz, M Versluis and N de Jong, Harmonic Chirp Imaging Method for Ultrasound Contrast Agent, IEEE Trans. Ultrason Ferrorelec Freq Contr, 2005; 52(2), 241-9（被引用29次ISI） 

10. R J Eckersley, C T Chin, P N Burns, Optimising Phase and Amplitude Modulation Schemes for Imaging Microbubble Contrast Agents at Low Acoustic Power; Ultrasound Med Biol. 2005; 31(2):213-9. （被引用37次ISI） 

11. J Borsboom, C T Chin, N de Jong, Experimental evaluation of a non-linear coded excitation method for contrast imaging, Ultrasonics 2004; 42:671-5. (被引用11次ISI) 

12. C T Chin, C Lancée, J M G Borsboom, F Mastik, N de Jong, M Versluis, D Lohse, Brandaris 128: a digital 25 million frames per second camera with 128 highly sensitive frames, Rev. Sci. Instruments, 2003; 74(12): 5026-34. （被引用61次ISI） 

13. J M G Borsboom, C T Chin, N de Jong, Non-linear coded excitation method for ultrasound contrast imaging, Ultrasound Med. Biol., 2003; 29:277-284. （被引用32次ISI） 

14. M Postema, A Bouakaz, C T Chin, N de Jong, Simulations and measurements of optical images of insonified ultrasound contrast microbubbles, IEEE Trans. Ultrason Ferrorelec Freq Contr, 2003; 50(5):523-36. （被引用25次ISI） 
 

15. C T Chin, P N Burns, Investigation of the effects of microbubble shell disruption on population scattering and implications for modeling contrast agent behaviour, IEEE Trans Ultrason Ferroelec Freq Contr, 2004; 51(3):286-92. 

16. C T Chin, P N Burns, Predicting the acoustic response of a micro bubble population for contrast imaging in medical ultrasound, Ultrasound Med Biol, 2000; 26:1289-96. （被引用20次ISI） 

17. D Hope Simpson, C T Chin, P N Burns, Pulse inversion Doppler: a new method for detecting nonlinear echoes from microbubble contrast agents, IEEE Trans Ultrason Ferroelec Freq Contr, 1999; 49:372-382.（被引用221次ISI） 

18. H Yamakoshi, C T Chin, S Jaimungal, P R Herman, L Zhao, G Kulcsar, F W Budnik, R S Marjoribanks, A Practical Self-Healing Mercury-Target for Efficient Generation of Soft X-Ray Radiation, Rev. Sci. Instrum., 65(6), 1964-1967 (1994) 

19. H Yamakoshi, C T Chin, S Jaimungal, P R Herman, L Zhao, G Kulcsar, F W Budnik, R S Marjoribanks, Extreme-ultraviolet Laser Photo-pumped by a Self-healing Hg Target, Applications of Laser Plasma Radiation, SPIE, vol. 2015, 227-231 (1993)  

 会议论文 

1.C T Chin, Dandan Deng, Yanbi Chen, Xing Ding, Yao Chen, Yinghui Liu, Siping Chen, and Tianfu Wang，A Multicenter Clinical Trial of HIFU Ablation of Uterine Fibroid, World Congress on Medical Physics and Biomedical Engineering., 2012. 

2.Jinjin Zhang, Siping Chen, Tianfu Wang, and C T Chin, Quantitative Investigation of Acoustic Response of Ultrasound Contrast Agent to Therapeutic Ultrasound. World Congress on Medical Physics and Biomedical Engineering., 2012. 

3. 张金金, 王国毅, 陈思平, 汪天富, 钱建庭, 治疗用超声微泡的定量声学测量的方法研究. 中国生物医学工程联合学术年会, 2011.  

4. Y Y Shen, X H Qiu, C T Chin, Finite Element Analysis of the Dynamic Behavior of an Ultrasound Microbubble within a Rigid Micro-Vessel, The 5th WACBE World Congress on Bioengineering, 2011, Taiwan. 

5. R Seip, B Raju, E Leyvi, C T Chin, S Li, C Rouse, D Koeberl, W Fodor, Enhanced gene transfection of plasmid DNA in the liver with ultrasound and microbubbles. IEEE Proc. Int. Ultrasonics Symp., 2010. 

6. A L Klibanov, T. Shevchenko, Z. Du, B Kundu, R Seip, B Raju, C T Chin, “Drugless” Tumor Therapy by Image-Guided Insonation of Microbubbles in the Tumor Vasculature: Possible Mechanisms of Action. 3rd Annual Image-Guided Therapy Workshop, National Center for Image Guided Therapy, Washington DC, 2010.  

7. A L Klibanov, T I Shevchenko, B I Raju, R Seip, C T Chin, Ultrasound-triggered release of materials entrapped in microbubble-liposome constructs: a tool for targeted drug delivery. 11th European Symp. Controlled Drug Delivery, Egmond aan Zee, The Netherlands, 2010 
 

8. M R Bohmer, C H T Chlon, B I Raju, C T Chin, T I Shevchenko, A L Klibanov, Acoustic activation of microbubbles for enhanced transport across the endothelial border, 11th European Symp. Controlled Drug Delivery, Egmond aan Zee, The Netherlands, 2010. (invited) 

9. A L Klibanov, T I Shevchenko, B Kundu, Z Du, M Bohmer, B I Raju, R Seip, C T Chin, Tumor therapy by microbubbles and ultrasound: mechanism of tumor growth control, 15th European Symp. Ultrasound Contrast Imaging, Rotterdam 2010.  

10. C T Chin, A Ghanem, C Troatz, C Hall, K Tiemann, Ultrasound mediated gene silencing with short-hairpin RNA, IEEE Int. Ultrasonics Symp., 2009. 

11. C T Chin, T Shevchenko, B I Raju, A L Klibanov, Control and reversal of tumor growth by ultrasound activated microbubbles, IEEE Int. Ultrasonics Symp., 2009. 

12. A L Klibanov, T Shevchenko, M Celebi, C Hall, C T Chin, Reduction of blood flow in the tumor vasculature after microbubble destruction by ultrasound, Radiological Soc. N. Am., 2009. 

13. A L Klibanov, T Shevchenko, M Kundu, M R Bohmer, R Seip, B I Raju, C T Chin, Destruction of microbubbles in the tumor vasculature by focused ultrasound inhibits tumor growth and reduces tumor size, World Mol. Imaging Congress, 2009. (invited) 

14. A Ghanem, C Steingen, F Brenig, Z-Y Bai, C Hall, C T Chin, G Nickenig, W Bloch, K Tiemann, Ultrasound-induced stimulation of microbubbles augments and targets myocardial engraftment of mesenchymal stem cells in vivo, Am Heart Assoc, 2008. 

15. K Tiemann, C T Chin, C S Hall, From targeted imaging to targeted therapy: local gene-delivery in cardiovascular structures, 13th Euro. Symp. Ultrasound Contrast Imaging, 2008. 

16. C T Chin, T I Shevchenko, B Verhaagen, A L Klibanov, Liposome-microbubble pendants allow ultrasound-triggered release of liposome contents, MR Guided Focused Ultrasound Surgery Int. Symp., 2008 

17. T I Shevchenko, C T Chin, and A L Klibanov, Liquid perfluorocarbon droplets: ultrasound-activated enhancers of ultrasound imaging and therapy, MR Guided Focused Ultrasound Surgery Int. Symp., 2008 

18. A L Klibanov, M Celebi, C T Chin, J J Rychak, K Ley, Intravascular Delivery and Sustained Release of Ultrasound Contrast Microbubbles via Intraperitoneal Administration, Controlled Release Soc., 2007 

19. W. T. Shi, M. Böhmer, A. van Wamel, M. Celebi, A. L. Klibanov, C T Chin, M. Emmer, K. Kooiman, N. de Jong, C. S. Hall, Ultrasound Therapy with Drug Loaded Microcapsules, IEEE Ultrasonics Symp, 2007. 

20. C T Chin, C Hall, A S Klibanov, A Controlled In-vitro Investigation of Ultrasound-mediated Drug Delivery, IEEE Ultrasonics Symp, 2006. 

21. M Versluis, Philippe Marmottant, Sascha Hilgenfeldt, and Claus-Dieter Ohl, C T Chin, A van Wamel, and N de Jong, D Lohse, Ultra-high-speed imaging of bubbles interacting with cells and tissue, 152nd Meeting Acoust. Soc. Am, December 2006. 
 

22. C T Chin, A van Wamel, M Emmer, N de Jong, C Hall, A S Klibanov, Mechanisms of Ultrasonicaly-Mediated Drug Delivery: High-Speed Camera Observations of Microbubbles with Attached Microbeads, IEEE Ultrasonics Symp., 2005. 

23. M Versluis, S M van der Meer, D Lohse, P Palanchon, D Goertz, C T Chin, N de Jong, Microbubble surface modes, IEEE Ultrasonics Symp., 2004. 

24. C T Chin, M Versluis, C Lancée, N de Jong, Free and Forced Oscillation of Microbubbles Observed using a New 25 Million Frames per Second Camera, IEEE Ultrasonics Symp., 2003. 

25. C T Chin, J Borsboom, N de Jong, Improved Frame Rate by Reduction of Bubble Destruction using Nonlinear Coded Excitations, IEEE Ultrasonics Symp., 2003. 

26. J Borsboom, C T Chin, N de Jong, In Vitro B-mode Contrast Imaging using Chirp Excitation with a Non-linear Decoder, IEEE Ultrasonics Symp., 2003. 

27. D E Goertz, M E Frijlink, A Bouakaz, C T Chin, N de Jong, A F W van der Steen, Effect of Bubble Size Distribution on Nonlinear Scattering from Microbubbles at High Frequencies, IEEE Ultrasonics Symp., 2003. 

28. M Versluis, D Lohse, N de Jong, C T Chin, C Lancee, J Honkoop, F Mastik, High-speed optical imaging of microbubble dynamics at 40 ns time scale, Euromech Fluid Mechanics Conf. (Toulouse) 2003. 

29. J Borsboom, C T Chin, N de Jong, Experimental evaluation of a non-linear coded excitation method for contrast imaging, Ultrasonics International (Granada), 2003. 

30. C T Chin, N de Jong, C Lancée, J Borsboom, F Mastik, M Versluis, D Lohse, Optical imaging of ultrasound contrast bubble motions at 25 million frames per second, 4th Int Symp Ultrasound Contrast Imaging (Tokyo), 2002. 

31. C T Chin, A Bouakaz, J Borsboom, N de Jong, Super harmonics and nonlinear coded excitation: two new detection methods for ultrasound contrast imaging, 4th Int Symp Ultrasound Contrast Imaging (Tokyo), 2002. 

32. N de Jong, C T Chin, C Lancée, J Borsboom, F Mastik, M Versluis, D Lohse, Brandaris 128: A rotating mirror digital camera with 128 frames at 25 Mfps, Int Conf High Speed Photography Photonics (Beaune), 2002. 

33. M Postema, A Bouakaz, C T Chin, N de Jong, Optically observed microbubble coalescence and collapse, Proc IEEE Ultrason Symp 2002. 

34. J Borsboom, C T Chin, N de Jong, Chirped excitation for contrast agent imaging: simulations and measurements, Proc IEEE Ultrason Symp 2002. 

35. D E Goertz, S W S Wong, E Cherin, C T Chin, P N Burns, F S Foster, Non-linear scattering properties of microbubble contrast agents at high frequencies, Proc IEEE Ultrason Symp 2001. 

36. C T Chin, R Kharchakdjian, P N Burns, A Simple Model of the Vascular Network for the Analysis of Destruction Reperfusion Mesaurements, The 6th Euro. Symp on Ultrasound Contrast Imaging 2001. (invited) 
 

37. C T Chin, The Effects of the Bubble Shell on Single-Pulse Nonlinear Scattering by Contrast Agents, The 5th Euro. Symp on Ultrasound Contrast Imaging 2000. (invited) 

38. C T Chin, P N Burns, Predicting acoustic response of a microbubble population for contrast imaging, Proc IEEE Ultrason Symp 1997 

39. P N Burns, J E Powers, D Hope Simpson, A Brezina, A Kolin, C T Chin, V Uhlendorf, T Fritzsch, Harmonic Power Mode Doppler using Microbubble Contrast Agents: an Improved Method for Small Vessel Flow Imaging, Proc IEEE Ultrason Symp 1994